Identified risk factors for early neuropsychological development at the INMA PROJECT

Ibarluzea, J. . 1, 2, 3 , Santa Marina, L. . 1, 2, 3 , Basterrechea, M. . 1, 2 , Lertxundi, A. . 2, 4 , Lertxundi, N. . 2, 5 , Fano, E. 2, 5 , Vegas, O. . 2, 5 , Amiano, P. . 1, 2, 3 , Arranz, E. . 2, 5 & Martínez , M. D. 2, 6

1 Subdirección Salud Pública Gipuzkoa
2 BIODONOSTIA
3 CIBERESP: Grupo 28
4 Facultadde Medicina de la UPV-EHU
5 Facultad de Psicología de la UPV-EHU
6 Consejería de Medio Ambiente

The INMA (INfancia y Medio Ambiente [Environment and Childhood]) project, aims to study the impact of environmental risk factors, both for physical and neuropsychological development. Our results are based on a prospective epidemiological birth-cohort study, with a longitudinal mother-child dyads monitoring: At pregnancy, birth and the first, second and fourth year of life. The project is composed by seven cohorts: Menorca, Flix (Tarragona), Granada, Valencia, Sabadell, Asturias and Gipuzkoa, sharing tools and study methodology.

Identified risk factors for neuropsychological development and specifically for cognitive and/or psychomotor development, assessed with the Bayley Scales (at age 1) and McCarthy Scales (at age 4), are as follows: a) iodine supplementation in pregnancy ?150 mg/day, b) exposure to organohalogen compounds (DDE , HCB , lindane, Mirex and PCBs), c) exposition to polybrominated-diphenyl ethers and perfluorinated compounds, d) exposure to Hg (methyl-Hg) and Pb, e) air pollutants, both indoor (passive smoking, gas cooking, NO2) and outdoor (PM2.5, NO2). As well as results of ongoing researches such as; cognitive development and endocrine disruptors, the poor urban environment effect and those related to maternal diet during pregnancy: low levels of antioxidants and Vitamin D, or mothers obesity effect will also be presented. The gene-environment interactions may increase the mentioned risks factors (GSTP1 polymorphisms).