A longitudinal approach to the influence of oxidative stress in cognition in affective and non-affective psychosis

Martinez-Cengotitabengoa, M. 1, 2, 3 , Arango, C. 1, 4 , Mico, J. A. 1, 5 , Castro-Fornieles, J. 1, 6 , Graell, M. 7 , Paya, B. 8 , Baeza, I. 9 & Gonzalez-Pinto, A. 1, 2, 10

1 Centro de Investigación Biomédica en Red de Salud Mental-CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain
2 Department of Psychiatry, Hospital Universitario de Alava, Vitoria, Spain
3 National Distance Education University (UNED)-Centro asociado de Vitoria, Spain
4 Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM ,Madrid, Spain. Medicine School, Universidad Complutense, Madrid, Spain.
5 Neuropsychopharmacology and Psychobiology Research Group, University of Cadiz, Cadiz, Spain
6 Department of Child and Adolescent Psychiatry and Psychology, SGR-1119, Neurosciences Institute, Hospital Clinic, IDIBAPS., Barcelona, Spain. Department of Psychiatry and Psychobiology, University of Barcelona, Spain
7 Department of Child and Adolescent Psychiatry and Psychology, University Hospital Niño Jesús, Madrid , Spain.
8 Child and Adolescent Psychiatry and Psychology Unit, University Hospital Marques de Valdecilla, Santander, Spain
9 Department of Psychiatry, Clinic Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
10 University of the Basque Country, Spain.

STUDY OBJECTIVES
To examine the association of baseline total antioxidant status (TAS) and glutathione (GSH) levels with short and long-term cognitive functioning in patients with early onset first-episode psychosis (FEP), comparing affective and non-affective psychosis
SUBJECTS AND METHODS

80 patients (9-17 years) with a FEP and 97 healthy controls were included in the study.
Blood samples were taken at admission for measurement of TAS and GSH and cognitive performance was assessed at baseline and 2 years after.

Linear regression analysis was used to assess the relationship between TAS or GSH levels ar baseline with cognitive performance at both time points, controlling for confounders (tobacco use, antipsychotics consumption and socioeconomic status)

RESULTS

We found a significant relationship between baseline TAS and cognition, both at baseline and 2 years after, in the whole sample. By cognitive domain, oxidative stress appeared exert influence in attention and working memory at baseline, and in attention and memory at the 2 years assessment time.
Exploring the results by diagnostic group only the non-affective patients showed the relation between oxidative damage and cognition.

CONCLUSION

The insult of oxidative stress in cognitive performance affects affective and non-affective psychotic patients in a differente manner , both at baseline and 2 years after the illness onser, being present only in the group of non-affective psychosis.