OS_17. 1 - Functional neuroimaging language profiles modeled with distributed sources

Diaz, J. & Mesa, I.

CEIT. San Sebastian, Spain.

For several years, researchers have been working on assessing hemispheric dominance for receptive language by using magnetoencephalography. As a result, a normative analysis for deriving brain activation profiles from single dipole models has been established. The main objectives of this study are 1) to perform a normative analysis of language profiles estimating distributed sources of brain activity and 2) to compare this analysis with other performed using single dipoles. Thus, a large sample of individuals were analyzed to observe if the features vary with stimulus presentation parameters, including the modality of presentation, task characteristics, or by the age or gender of the participants; and if the features happen to be similar to the ones found in single dipole models. For auditory tasks, as with single dipole models, the profile of activity detected in the middle temporal gyrus and perisylvian regions were consistently higher than the rest of the regions. For visual tasks, on the contrary, the perisylvian region happened to be low activated. Regarding the language lateralization, as the single dipole model, for the later components (>150ms) the activity found in the left temporal lobe is higher than in the right, but on the contrary, no statistical significance was found.