Activities and Seminars

Mari Cruz Rodigruez-Oroz. Impulse control disorders in Parkinson’s disease.
Date: Oct 17, 2013

What: Impulse control disorders in Parkinson's disease.

Where: BCBL auditorium

Who: Mari Cruz Rodigruez-Oroz, Senior Ikerbasque Professor at the BioDonostia Research Institute in San Sebastian.

When: 12 noon

Dopaminergic treatments in Parkinson’s disease (PD) are associated in 13 % of patients with impulse control disorders (ICD) that includes dopamine dysregulation syndrome (DDS), characterized by an addictive excessive dopaminergic therapy, compulsive gambling, buying, sex activity and eating, and stereotyped behaviors, typically punding and hobbying. The pathophysiology of this disorder is not well understood. Recent studies with DAT(dopamine transporter)-SCAN or PET with raclopride (D2 agonits) have shown that PD patients with ICD have less DAT density and higher concentration of dopamine after a dose of L-dopa in the ventral striatum than patients without ICD. Moreover, human studies with fMRI and H20-PET demonstrate that these patients have a different activation of the limbic-associative circuit (ventral estriatum – frontal cortex). In addition, the subhtalamic nucleus (STN) also has a different neuronal oscillatory activity in the ventral portion (limbic-associative territory) in PD patients with ICD than in patients without ICD. Thus, ICD in PD can be due to a hyperdominergic stimulation in the ventral striatum that drives a different pattern of activation in the limbic and associative circuits including the basal ganglia and the cerebral cortex.