Activities and Seminars

Miguel Valencia. Oscillatory activity in of Parkinson’s disease; clinical and experimental applications.
Date: Apr 09, 2014

What: Oscillatory activity in of Parkinson's disease; clinical and experimental applications.

Where: BCBL auditorium

Who: Miguel Valencia, PhD., Centro de Investigacion Medica Aplicada (CIMA), Universidad de Navarra.

When: 12 noon

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, only after Alzheimer’s disease. The main clinical features of PD are resting tremor, rigidity, slowness of voluntary muscle movements (bradykinesia), decreased automatic movements and postural instability. Electrophysiologically, PD is characterized by the presence of abnormal oscillatory activity at different points of the basal ganglia. In the subthalamic nucleus (STN), the most commonly structure studied in PD patients, activities in the theta, beta, gamma and high-frequency (300 Hz) ranges have been described. Beta activity has been shown to have a correlation with clinical symptoms, like rigidity and bradykinesia. Low frequency oscillations have been associated with different drug side-effects and a dependence of the amplitude of fast frequencies on the phase of slower frequencies have been recently described.  In this talk I’ll review some of this findings with a focus on the different signal processing techniques we use to evaluate how brain oscillatory activity is altered both in PD patients and in animal models of the disease.